Life Long Echoes

Life-Long Echoes - A Critical Analysis of the Developmental Origins of Adult Disease Model Peter D. Gluckmana, Mark A. Hansonb, Susan M.B. Mortona, c, Catherine S. Pinal

Abstract


The hypothesis that there is a developmental component to subsequent adult disease initially arose from epidemiological findings relating birth size to either indices of disease risk or actual disease prevalence in later life. While components of the epidemiological analyses have been challenged, there is strong evidence that developmental factors contribute to the later risk of metabolic disease - including insulin resistance, obesity, and heart disease - as well as have a broader impact on osteoporosis, depression and schizophrenia. We suggest that disease risk is greater when there is a mismatch between the early developmental environment (i.e., the phase of developmental plasticity) versus that experienced in mature life (i.e., adulthood), and that nutritional influences are particularly important. It is also critical to distinguish between those factors acting during the developmental phase that disrupt development from those influences that are less extreme and act through regulated processes of epigenetic change. A modelof the relationship between the developmental and mature environment is proposed and suggests interventional strategies that will vary in different population settings.


Neil B. Metcalfe and and Pat Monaghan, 2003. Growth versus lifespan: perspectives from evolutionary ecology, Experimental Gerontology Volume 38, Issue 9 , 1 September 2003, Pages 935-940


Marc Mangel and Stephan B. Munch, 2005. A Life-History Perspective on Short- and Long-Term Consequences of Compensatory Growth, the american naturalist, vol. 166, no. 6, December 2005


Peter D. Gluckman, Mark A. Hanson and Hamish G. Spencer, 2005, Predictive adaptive responses and human evolution,TRENDS in Ecology and Evolution Vol.20 No.10 October 2005


ROBERT E. RICKLEFS & ALEX SCHEUERLEIN, 2005, Life Span in the Light of Avian Life Histories

Ruth Mace, 2000. Evolutionary ecology of human life history, ANIMAL BEHAVIOUR, 2000, 59, 1–10